Sigma Aldrich

Biochemical and organic chemical products

In 1955 Alfred Bader founded the Aldrich Chemical Company at Queen’s University in Canada and at Harvard University. In 1975 Aldrich Chemicals merged with Sigma in St. Louis.

Jai Nagarkatti (CEO, President)
Mike Hogan (CFO)

Nina Fedoroff
David Harvey
Lee McCollum
Jai Nagarkatti
Avi Nash
William O’Neil
Pedro Reinhard
Timothy Sear
Dean Spatz
Barrett Toan

3050 Spruce St.
St. Louis, MO 63103
USA
Phone: +1-314-771-5765
Fax: +1-314-771-5757

The Panorama™ Human Protein Function Microarray contains a set of 130 human proteins involved in cancer. The protein content has been selected based on “A Census of Human Cancer Genes”, recently published by Michael R. Stratton and co-workers from the Wellcome Trust Sanger Institute in Hinxton, UK, who have compiled a set of 291 cancer genes. The selected cancer genes have a causal link in oncogenesis and mutations in these genes are implicated in cancer development. The proteins encoded by these genes regulate processes such as cell proliferation, cell differentiation, cell death and DNA-repair.

130 cancer related proteins have been expressed and arrayed so that they are functional, active and oriented on the microarray surface for evaluation of their function in a parallel format.

The cancer related proteins and seven controls are spotted in quadruplicate in a single grid per Panorama™ slide. All arrayed cancer related proteins correspond to the full-length cDNAs from sequence verified clones.

The glass slide format is compatible with conventional microarray scanners
and instrumentation, enabling bind and wash assays for protein activity using analytes or ligands such as nucleic acids, proteins and small molecules.

The Panorama™ Human Protein Function Microarray can be used to study all types of protein activity including protein interactions, binding
kinetics and the effects of small molecule and drug inhibition.